Journal article
Clinical Behavior of Breast Cancer in Young BRCA Carriers and Prediagnostic Awareness of Germline BRCA Status
M Lambertini, E Blondeaux, LM Tomasello, E Agostinetto, AS Hamy, HJ Kim, MA Franzoi, R Bernstein-Molho, F Hilbers, K Pogoda, H Wildiers, J Bajpai, M Ignatiadis, HCF Moore, AH Partridge, KA Phillips, A Toss, C Rousset-Jablonski, C Criscitiello, T Renaud Show all
Journal of Clinical Oncology | Published : 2025
DOI: 10.1200/JCO-24-01334
Abstract
PURPOSE To investigate the clinical behavior of breast cancer in young BRCA carriers according to the specific BRCA gene (BRCA1 v BRCA2) and the association of the timing of genetic testing (before v at diagnosis) with prognosis. METHODS This was an international, multicenter, hospital-based, retrospective cohort study that included 4,752 patients harboring germline pathogenic/likely pathogenic variants (PVs) in BRCA1 or BRCA2, who were diagnosed with stage I-III invasive breast cancer at 40 years or younger between January 2000 and December 2020 in 78 centers worldwide (ClinicalTrials.gov identifier: NCT03673306). RESULTS Compared with BRCA2 carriers (n 5 1,683), BRCA1 carriers (n 5 3,069) ..
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